Add-on perampanel in Lance–Adams syndrome

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Add-on perampanel in Lance–Adams syndrome

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Perampanel is among the latest AEDs approved, indicated for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures, in patients aged 12 years and older. This paper summarizes the clinical recommendations on the current role of perampanel in the treatment of pediatric epilepsies and future directions for research. The o...

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OBJECTIVE The liver plays a major role in the metabolism and elimination of many antiepileptic drugs (AEDs), including perampanel. Some of the metabolites identified for perampanel are likely formed via reactive intermediates, which have the potential to covalently bind to protein and cause idiosyncratic toxicities, including hepatotoxicity. The approved AED perampanel is a selective, noncompet...

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ژورنال

عنوان ژورنال: Epilepsy & Behavior Case Reports

سال: 2016

ISSN: 2213-3232

DOI: 10.1016/j.ebcr.2016.05.001