منابع مشابه
Add-on perampanel in Lance–Adams syndrome
Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated for patients with partial-onset and primary generalized tonic-clonic seizures. A positive effect was reported in some patients with epileptic myoclonic jerks in idiopathic genera...
متن کاملPerampanel (Fycompa)
INTRODUCTION Epilepsy is a serious neurological condition that affects more than 50 million individuals globally, 80% of whom live in developing countries.1,2 An estimated 1.7% of U.S. adults have been diagnosed with the condition.3 From prominent historical fi gures, such as Julius Caesar and Vladimir Lenin, to friends or family members, most people probably know someone affected by epilepsy.2...
متن کاملCurrent role of perampanel in pediatric epilepsy
Perampanel is among the latest AEDs approved, indicated for the treatment of partial-onset seizures with or without secondary generalization, and for primary generalized tonic-clonic seizures, in patients aged 12 years and older. This paper summarizes the clinical recommendations on the current role of perampanel in the treatment of pediatric epilepsies and future directions for research. The o...
متن کاملOpen-label add-on treatment trial of minocycline in fragile X syndrome
BACKGROUND Fragile X syndrome (FXS) is a disorder characterized by a variety of disabilities, including cognitive deficits, attention-deficit/hyperactivity disorder, autism, and other socio-emotional problems. It is hypothesized that the absence of the fragile X mental retardation protein (FMRP) leads to higher levels of matrix metallo-proteinase-9 activity (MMP-9) in the brain. Minocycline inh...
متن کاملAbsence of Liver Toxicity in Perampanel-Treated Subjects: Pooled results from partial seizure phase III perampanel clinical studies
OBJECTIVE The liver plays a major role in the metabolism and elimination of many antiepileptic drugs (AEDs), including perampanel. Some of the metabolites identified for perampanel are likely formed via reactive intermediates, which have the potential to covalently bind to protein and cause idiosyncratic toxicities, including hepatotoxicity. The approved AED perampanel is a selective, noncompet...
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ژورنال
عنوان ژورنال: Epilepsy & Behavior Case Reports
سال: 2016
ISSN: 2213-3232
DOI: 10.1016/j.ebcr.2016.05.001